Intramuscular fatty acid metabolism in contracting and non‐contracting human skeletal muscle
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چکیده
منابع مشابه
Fatty acid oxidation in human skeletal muscle.
In this issue of the JCI, Rasmussen et al. (1) describe the functional regulation of fatty acid oxidation by hyperglycemia and hyperinsulinemia in human skeletal muscle. The authors report inhibition of long-chain fatty acid (LCFA) oxidation, but not medium-chain fatty acid (MCFA) oxidation, in association with increased intramyocellular malonyl-CoA concentrations. Normally, a glucose infusion ...
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We hypothesized that insulin alters plasma free fatty acid (FFA) trafficking into intramyocellular (im) long-chain acylcarnitines (imLCAC) and triglycerides (imTG). Overnight-fasted adults (n = 41) received intravenous infusions of [U-¹³C]palmitate (0400-0900 h) and [U-¹³C]oleate (0800-1400 h) to label imTG and imLCAC. A euglycemic-hyperinsulinemic (1.0 mU·kg fat-free mass⁻¹·min⁻¹) clamp (0800-...
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We evaluated the applicability of stable isotopic tracers to the study of intramuscular fatty acid metabolism by infusing both [U-13C]palmitate and [1-13C]oleate intravenously for 4 h into fasted conscious rats. Skeletal muscles were sequentially biopsied, and the concentration and 13C enrichment of fatty acids were measured by gas chromatography/combustion/isotope ratio mass spectrometry. Thro...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2002
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jphysiol.2001.013912